Naltrexone for cholestatic itch: a systematic review
...In all five studies performing statistical analysis, naltrexone significantly reduced pruritus compared with baseline. 37% of patients reported side effects, notably opioid withdrawal-type reactions and recurrence of previous pain, from all pathologies....
https://spcare.bmj.com/content/11/2/217
Low-dose naltrexone for treatment of dermatologic conditions: A ...
...Naltrexone has been used to treat pruritus at higher doses, including pruritus secondary to polycythemia vera, uremic pruritus, and aquagenic pruritus. The mechanism of action is suppression of endogenous opioids, thereby reducing central and peripheral itch sensations....
https://www.jaad.org/article/S0190-9622(25)02812-9/fulltext
Naltrexone and naloxone - DermNet
...Naltrexone and naloxone are both competitive antagonists of opioid receptors, binding with high affinity to the mu (?) opioid receptors. These two drugs, including low-dose naltrexone (LDN), are used off-label in the treatment of several dermatological conditions....
https://dermnetnz.org/topics/naltrexone-and-naloxone
Naltrexone for Pruritus ? Therapeutic Cheat Sheet - Next Steps in ...
...Patients also frequently experience symptoms of scalp itch, pain, and burning. To date, there are no long-term remittive nor curative therapies available. Low-dose naltrexone has anti-inflammatory properties and has recently been described in the context of treating autoimmune conditions....
https://nextstepsinderm.com/derm-topics/naltrexone-for-pruritus-therapeutic-cheat-sheet/
Naltrexone for cholestatic itch: a systematic review - PubMed
...Oral naltrexone therapy helps relieve cholestatic itch and although it should be used with caution in patients using exogenous opioids for analgesia, it should be considered when treating refractory pruritus in patients with end-stage liver disease....
https://pubmed.ncbi.nlm.nih.gov/33692114/
An Update on the Off-Label Uses of Low-Dose Naltrexone in Dermatology
...One month after initiating naltrexone 1.5 mg daily, the patient?s scalp pruritus and burning sensation resolved and their facial erythema and cutaneous lesions started to clear....
https://jddonline.com/articles/an-update-on-off-label-uses-of-low-dose-naltrexone-in-dermatology-S1545961624P1224X
Low-dose naltrexone in dermatology: A brief review
...The safety and efficacy of low-dose naltrexone in the management of chronic pain and inflammation in multiple sclerosis, Fibromyalgia, crohn's disease, and other chronic pain disorders....
https://cosmoderma.org/low-dose-naltrexone-in-dermatology-a-brief-review/
Low-dose naltrexone for treatment of dermatologic conditions: A ...
...Naltrexone has been used to treat pruritus at higher doses, including pruritus secondary to polycythemia vera, uremic pruritus, and aquagenic pruritus. The mechanism of action is suppression of endogenous opioids, thereby reducing central and peripheral itch sensations....
https://www.sciencedirect.com/science/article/pii/S0190962225028129
Does Naltrexone Stop Itching? Treatment for Chronic Pruritus
...Yes, naltrexone can stop itching in some cases by blocking opioid receptors. Discover how this medication works for chronic pruritus and what conditions it can effectively treat....
https://medxdrg.com/does-naltrexone-stop-itching-understanding-opioid-antagonists-for-chronic-pruritus
Low-dose naltrexone for treatment of dermatologic conditions: A ...
...Low-dose naltrexone (LDN) transiently blocks the opioid receptor, resulting in increased ligand and receptor expression, favoring ? over ? receptors and decreasing inflammatory mediators and itch....
https://pubmed.ncbi.nlm.nih.gov/40962192/