Quel est l?effet de la P21 dans la fonction cellulaire
...Résumé La p21 est un inhibiteur du cycle cellulaire qui est impliqué dans des processus cellulaires essentiels tels que l?arrêt du cycle cellulaire, l?apoptose et la régulation transcriptionnelle, ainsi que la différenciation, la sénescence et la réparation de l?ADN....
https://tomasrosprim.com/fr/quel-est-leffet-de-la-p21-dans-la-fonction-cellulaire/
p21 - Wikipedia
...Recent work exploring p21 activation in response to DNA damage at a single-cell level have demonstrated that pulsatile p53 activity leads to subsequent pulses of p21, and that the strength of p21 activation is cell cycle phase dependent. [28]...
https://en.wikipedia.org/wiki/P21
What Is the Role of p21 in the Cell Cycle? - ScienceInsights
...The protein p21 plays a central role in human biology, acting primarily as a powerful brake on the cell division cycle. It ensures that cells do not multiply under unfavorable conditions....
https://scienceinsights.org/what-is-the-role-of-p21-in-the-cell-cycle/
P21 ? Wikipédia
...p21Cip1 (ou p21 Waf1), également connue sous le nom de cyclin-dependent kinase inhibitor 1 ou CDK-interacting protein 1 est une protéine inhibitrice des CDK. Elle est connue pour inhiber les complexes CDK2 et CDK4 et permettre ainsi l'arrêt du cycle cellulaire....
https://fr.wikipedia.org/wiki/P21
The role of p21 in cellular senescence and aging-related diseases
...This article offers a comprehensive overview of 3 senescence phenotypes involving p21, elucidates the differences between p21 and p16, and examines the role of p21-dependent senescence in the pathogenesis of various diseases....
https://www.sciencedirect.com/science/article/pii/S1016847824001389
P21 - an overview | ScienceDirect Topics
...As a downstream target of p53, p21 is a powerful pan-inhibitor of CDK that plays a considerable role in cell cycle regulation, DNA repair, and cellular senescence [57,68,69]....
https://www.sciencedirect.com/topics/medicine-and-dentistry/p21
p21 Protein: Role in Cell Cycle, Cancer, and Aging
...The p21 protein is a fundamental regulator of cell behavior. Encoded by the CDKN1A gene, p21 is a cyclin-dependent kinase inhibitor that governs the pace of cell division....
https://biologyinsights.com/p21-protein-role-in-cell-cycle-cancer-and-aging/
p21 in cancer: intricate networks and multiple activities - Nature
...p21 has a well-known role in mediating p53-induced growth arrest. However, this protein can affect many other cellular functions and is activated independently of p53....
https://www.nature.com/articles/nrc2657
p21 : une protéine pour régir le destin cellulaire
...Abstract L?expression précoce de p21 contrôle le destin de prolifération/sénescence des cellules après la chimiothérapie. Lorsque le cancer est traité par chimiothérapie, les cellules survivantes peuvent acquérir un phénotype prolifératif ou sénescent....
https://lilinguas.com/fr/p21-une-prot%C3%A9ine-pour-r%C3%A9gir-le-destin-cellulaire/
Dual role of p21 in regulating apoptosis and mitotic integrity in ...
...In summary, p21 functions as a dual regulator in response to DNA damage, promoting apoptosis at HD and preventing mitotic failure at LD....
https://www.nature.com/articles/s41420-025-02416-w