High-Throughput Screening: today?s biochemical and cell-based ...
...High-throughput screening (HTS) provides starting chemical matter in the adventure of developing a new drug. In this review, we survey several HTS methods used today for hit identification, organized in two main flavors: biochemical and cell-based assays. Biochemical assays discussed include fluorescence polarization and anisotropy, FRET, TR-FRET, and fluorescence lifetime analysis. Binding ......
https://www.sciencedirect.com/science/article/pii/S1359644620303056
High-Throughput Approaches for Screening and Analysis of Cell Behaviors
...In recent years, researchers have developed high-throughput (HT) approaches that enable the analysis of hundreds to thousands of interactions among biomaterials, biomolecules, and cells on the same platform for drug screening, toxicology, and investigation of cellular responses [5, 6]....
https://pmc.ncbi.nlm.nih.gov/articles/PMC5702937/
iQue® High-Throughput Screening (HTS) by Cytometry for Cell Line ...
...The iQue ® 3 HTS Cytometry Platform with iQue ® Human IgG Titer and Viability Kit is a high-throughput suspension cell and bead-based analysis platform for clone screening. It provides greater insight into production clone ranking and selection with rapid and simultaneous evaluation of IgG titer, specific productivity and cell health....
https://www.sartorius.com/en/applications/biopharmaceutical-manufacturing/cell-line-development/cld-instruments/ique-high-throughput-screening-by-cytometry-for-cell-line-development
High-Content Screening (HCS) and High-Content Analysis (HCA)
...High-throughput for the highest quality and fastest time-to-data possible Our CellInsight CX7 LZR Pro, CX7 LED Pro, and CX5 high-content imaging platforms are designed for exceptional single-cell analysis capabilities and lightning-fast time-to-data....
https://www.thermofisher.com/us/en/home/life-science/cell-analysis/cellular-imaging/hcs-hca.html
High-Throughput Screening (HTS) - Beckman
...Biomek workstations provide comprehensive, tailored solutions for high-throughput screening workflows. Beyond robust instrumentation, we provide data-rich software, deep workflow and application expertise, custom engineering, service plans and a broad range of supporting resources....
https://www.beckman.com/resources/biologics-drug-discovery-and-development/assay-development/high-throughput-screening
High-Throughput Screening in Drug Discovery Explained - Technology Networks
...Understand how high-throughput screening works and why it's crucial for faster, more efficient small molecule and biologics discovery....
https://www.technologynetworks.com/drug-discovery/articles/high-throughput-screening-principles-applications-and-advancements-405121
Microfluidics for High Throughput Screening of Biological Agents and ...
...Microfluidic devices have been widely used for gene analysis, immunoassays, organ-on-chip technology, cell engineering, and disease modeling. Their integration into high throughput screening (HTS) platforms has led to large-scale testing of various biological and chemical agents. This brief review discusses existing microfluidic HTS modalities, including the droplet mode, the perfusion mode ......
https://link.springer.com/article/10.1007/s44174-024-00169-1
Automated Cell Counting & Image Cytometry Solutions | Revvity
...The systems include Cellometer? automated cell counters, the Cellaca? MX high-throughput cell counter, the Cellaca PLX image cytometer, and the high-throughput Celigo? image cytometer. The instruments are complemented by reagents and kits for cell counting and cell viability assays, microplates, slides, and counting beads....
https://www.revvity.com/category/cell-counting-image-cytometry
High-throughput screening: accelerating drug discovery - Single Cell ...
...Automation in high-throughput screening Automation is pivotal in high-throughput screening. It helps the drug discovery process by streamlining experimental workflows, minimizing human error, and maximizing throughput and efficiency. From liquid handling robots to software that can perform advanced data analysis, automation can assist researchers at every step. Automation enables researchers ......
https://www.scdiscoveries.com/blog/high-throughput-screening-accelerate-drug-discovery/
Molecular Devices | Life Science Applications | Bioanalytical ...
...The drug discovery landscape is shifting, with more scientists centering cell line development, disease models, and high-throughput screening methods around physiologically-relevant 3D cell models....
https://www.moleculardevices.com/