Beyond transitional selection: New roles for BLyS in peripheral tolerance
...Herein, we review how BLyS contributes to the negative selection of autoreactive B cell clones from the preimmune repertoire as well as its role in regulating both germinal center and extrafollicular peripheral B cell responses....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272642/
The role of B lymphocyte stimulator in B cell biology: implications for ...
...Mounting evidence indicates that B cell tolerance can be either broken or modulated by deliberately manipulating BLyS levels, and belimumab, a BLyS-neutralizing antibody, was recently approved for the treatment of systemic lupus erythematosus (SLE)....
https://journals.sagepub.com/doi/10.1177/0961203312469453
effect of BLyS neutralization on primary B cell compartments and ...
...B lymphocyte stimulator (BLyS) controls the proportion of transitional B cells completing differentiation and the longevity of most primary B cells. These key roles in B cell selection, survival and homeostasis make BLyS and its receptors attractive candidates for targeted B cell therapeutics....
https://academic.oup.com/jimmunol/article/178/1_Supplement/LB6/8032578
NIH Public Access of Medicine, Philadelphia, PA 19104-6082 tolerance ...
...dence accumulated over the last decade firmly establishes BLyS as the limiting factor for which TR and mature primary B cells compete to survive. The BLyS family of ligands and receptors consists ......
https://www.researchgate.net/profile/Ann-Rothstein-2/publication/221822330_Beyond_transitional_selection_New_roles_for_BLyS_in_peripheral_tolerance/links/5c9eb9cb45851506d7341cc8/Beyond-transitional-selection-New-roles-for-BLyS-in-peripheral-tolerance.pdf
BLyS and B cell homeostasis - ScienceDirect
...The critical role of BLyS in B cell homeostasis is illustrated by the finding that ectopic expression, from a transgene or exogenous supplementation by injection, of recombinant BLyS expands follicular and marginal zone B cell populations, the major peripheral B cell subsets....
https://www.sciencedirect.com/science/article/pii/S1044532306000820
What Rheumatologists Should Know About B Cell Tolerance & Autoimmunity ...
...A recent Arthritis & Rheumatology review article explores the immune system?s mechanism for creating B cells that respond to diverse pathogens while preserving immune tolerance & highlights key insights for rheumatologists....
https://www.the-rheumatologist.org/article/what-rheumatologists-should-know-about-b-cell-tolerance-autoimmunity/
The BLyS Family: Toward a Molecular Understanding of B Cell Homeostasis ...
...Since these survival processes impact most B cell activities, members of the BLyS family have emerged as key players in the etiology and treatment of autoimmunity and neoplasia; and as attractive targets for the manipulation of humoral immunity in vaccine development and transplant tolerance....
https://pmc.ncbi.nlm.nih.gov/articles/PMC2654184/
Blockade of BLyS inhibits B-cell responses and antibody production for ...
...Here, we investigated the efficacy of the BLyS inhibitors belimumab and telitacicept in controlling B-cell response and preventing chronic rejection. The effects of belimumab and telitacicept on B-cell activation, differentiation, and antibody production in vitro were determined....
https://www.sciencedirect.com/science/article/pii/S1053249823021629
B Lymphocyte Homeostasis and BLyS Directed Immunotherapy in ...
...Recent advances in our understanding of B-lymphocyte homeostasis provide novel targets for immunomodulation in transplantation. Specifically, the TNF-related cytokine, BLyS, is the dominant survival factor for ?tolerance-susceptible? Transitional and ?preimmune? mature Follicular B-cells....
https://pmc.ncbi.nlm.nih.gov/articles/PMC2946495/
The role of B lymphocyte stimulator (BLyS) in systemic lupus ...
...High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE....
https://pmc.ncbi.nlm.nih.gov/articles/PMC2673851/