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Gata2 is a tissue-specific post-mitotic selector gene for midbrain ...
...These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain....
https://journals.biologists.com/dev/article/136/2/253/65402/Gata2-is-a-tissue-specific-post-mitotic-selector
Role of the pioneer transcription factor GATA2 in health and disease ...
...Although GATA2 is essential for hematopoiesis and lymphangiogenesis, it is also expressed in other tissues such as the lung, prostate gland, gastrointestinal tract, central nervous system, placenta, fetal liver, and fetal heart....
https://link.springer.com/article/10.1007/s00109-023-02359-8
Gata2, Nkx2-2 and Skor2 form a transcription factor network regulating ...
...As the transcription factor, Gata2 is required for the development of all GABAergic neurons derived from the embryonic mouse midbrain, we hypothesized that the genes expressed downstream of Gata2 could contribute to the diversification of GABAergic neuron subtypes in this brain region....
https://journals.biologists.com/dev/article/149/14/dev200937/276066/Gata2-Nkx2-2-and-Skor2-form-a-transcription-factor
GATA2 - an overview | ScienceDirect Topics
...Overexpression of Gata2 (Pou1f1-Gata2) causes a reduction in the expression domain of dorsal pituitary cell types and an expansion of ventral cell types at e16.5....
https://www.sciencedirect.com/topics/neuroscience/gata2
Region-resolved proteomic map of the human brain: functional ...
...While progress has been made in transcriptomic profiling of the human brain, functional characterization of brain regions and their interactions on the basis of regional protein e...
https://www.nature.com/articles/s41392-025-02554-8
Noncoding variants alter GATA2 expression in rhombomere 4 ... - Nature
...In the present study, we report that HCFP1 results from heterozygous duplications within a neuron-specific GATA2 regulatory region that includes two enhancers and one silencer, and from noncoding......
https://www.nature.com/articles/s41588-023-01424-9
Brain tissue expression of GATA2 - The Human Protein Atlas
...Summary of GATA2 (NFE1B) expression in human brain tissue. Nuclear expression in several tissues, mainly in seminal vesicle, placenta and prostate....
https://www.proteinatlas.org/ENSG00000179348-GATA2/brain
GATA2 ? Wikipédia
...Le GATA2 est une protéine appartenant ā la famille des facteurs de transcription de type GATA dont le gčne est le GATA2 situé sur le chromosome 3 humain. Il est exprimé dans les valves des vaisseaux lymphatiques et contribue aux développements de ces derničres 5....
https://fr.wikipedia.org/wiki/GATA2
GATA Transcription Factors: A Cross-Road for Erythropoiesis ...
...In CNS, during neuronal development, GATA2 confirms its role in stemness by maintaining the ventral neuronal progenitors and also leading GABAergic, serotoninergic, and sympathetic neuron differentiation....
https://onlinelibrary.wiley.com/doi/pdf/10.1002/dneu.22975
GATA2 - Wikipedia
...Inactivating mutations of the GATA2 gene cause a reduction in the cellular levels of GATA2 and the development of a wide range of familial hematological, immunological, lymphatic, and/or other disorders that are grouped together into a common disease termed GATA2 deficiency....
https://en.wikipedia.org/wiki/GATA2
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