Case Report of a Serious Adverse Event Following the Administration of ...
...We speculate that the large number of administered cells localized to the lung immediately following infusion and were triggered to release cytokine by the recognition of low levels of ERBB2 on lung epithelial cells....
https://www.sciencedirect.com/science/article/pii/S1525001616323425
ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung ... - Cell Press
...Liu et al. now show that ablation of Smad4 and Pten in the pulmonary epithelium results in the development of metastatic adenosquamous lung tumors through activation of the ErbB2/ELF3/AKT pathway. ErbB2 activation in mice is due to downregulation of Errfi1 expression, a direct target of SMAD4....
https://www.cell.com/cell-reports/fulltext/S2211-1247(15)00142-4
Tissue expression of ERBB2 - Staining in lung - The Human Protein Atlas
...Expression of ERBB2 (c-ERB-2, c-ERB2, CD340, HER-2, HER2, MLN-19, NEU, NGL, p185 (erbB2)) in lung tissue. Antibody staining with HPA001383, CAB000043, CAB020416 and CAB062555 in immunohistochemistry....
https://www.proteinatlas.org/ENSG00000141736-ERBB2/tissue/lung
ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and ...
...Mice with ablation of Pten and Smad4 in airway epithelium develop metastatic adenosquamous tumors. Comparative transcriptomic and in vivo cistromic analyses determine that loss of PTEN and SMAD4 results in ELF3 and ErbB2 pathway activation due to decreased expression of ERRFI1, a negative regulator of ERBB2 in mouse and human cells....
https://www.sciencedirect.com/science/article/pii/S2211124715001424
Heterogeneity of ERBB2 amplification in adenocarcinoma, squamous cell ...
...High-level ERBB2 amplification occurs in a small fraction of lung cancers with a strong propensity to high-grade adenocarcinomas. Heterogeneity of amplification may limit the utility of anti-HER2 ......
https://www.nature.com/articles/modpathol2012125
An ErbB2 splice variant lacking exon 16 drives lung carcinoma
...However, consistent with an antitumor immune response, ERBB2-positive regions of lung tissue from DOX-induced ERBB2-FL/CCSP-rtTA were infiltrated by CD8+ cytotoxic T cells that were interspersed among the ERBB2+ lung epithelial cells....
https://www.jstor.org/stable/26968611
ERBB2 Regulates MED24 during Cancer Progression in Mice with
...ERBB2 is an oncogenic driver with frequent gene mutations and amplification in human lung tumors and is an attractive target for lung cancer therapy. However, target therapies can be improved by understanding the in vivo mechanisms regulated by ERBB2 during lung tumor development. Here, we generated genetic mouse models to show that Erbb2 loss inhibited lung tumor development induced by ......
https://www.mdpi.com/2073-4409/8/6/615
ERBB2 protein expression summary - The Human Protein Atlas
...ERBB2 (c-ERB-2, c-ERB2, CD340, HER-2, HER2, MLN-19, NEU, NGL, p185 (erbB2)) protein expression summary....
https://www.proteinatlas.org/ENSG00000141736-ERBB2
EGFR Signaling in Lung Fibrosis - MDPI
...These authors demonstrated that treatment of airway epithelial cells with an anti-ErbB2 antibody, trastuzumab, induces their de-differentiation associated with an increase in the numbers of non-ciliated and metaplastic, flat cells....
https://www.mdpi.com/2073-4409/11/6/986
ERBB2-induced inflammation in lung carcinogenesis
...ERBB2/HER2/NEU, a member of the epidermal growth factor receptor family, is overexpressed in more than 25 % of non-small cell lung cancer and is considered to be a significant and independent prognostic factor in lung cancer. Here we generated a lung specific HER2 overexpressing transgenic mouse model. In this model, HER2 was driven by the human surfactant protein-C promoter to investigate the ......
https://link.springer.com/article/10.1007/s11033-012-1635-7
Functional analysis of receptor tyrosine kinase mutations in lung ...
...AALE human lung epithelial cells were simi-larly transformed to anchorage independence by the extracellular mutants of ERBB2 (Fig. 1 C and D). We have thus identi fied oncogenic somatic mutations of the extracellular domain of ERBB2 in lung and breast cancer, occurring at a rate of about 1%, approximately half that of the ERBB2 kinase domain ......
https://www.pnas.org/doi/pdf/10.1073/pnas.1203201109
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