A Crucial Role for Antigen Presenting Cells in Donor CD4+CD25 ...
...Several lines of evidence show that donor derived mature CD4 + CD25 + Foxp3 + regulatory T cells (Tregs) suppress experimental GVHD. The mechanism of GVHD suppression by donor Tregs is, however, not well understood....
https://ashpublications.org/blood/article/114/22/688/65091/A-Crucial-Role-for-Antigen-Presenting-Cells-in
Diverse roles of dendritic cell and regulatory T cell crosstalk in ...
...Treg-cell proliferation is controlled by antigen-presenting DCs. On the other hand, Treg cells suppress the function of DCs by restraining DC maturation. Therefore, the interaction between DCs and Treg cells, DC?Treg crosstalk, could contribute to controlling health and disease....
https://academic.oup.com/intimm/article/37/1/5/7702714
Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25
...The antigen-dependent expression of CD25 was at least twofold higher on Tregs than on Tcons, and this difference was maximal at intermediate antigen concentrations of MOG35-55 (320 nM?3.2 µM) (Figures 1 B,D)....
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01782/full
Using Anti-CD25 Antibodies to Target Regulatory T Cells
...A comprehensive guide on using anti-CD25 antibodies to target regulatory T cells in vivo, enhancing immune responses in various therapies....
https://ichor.bio/resources/targeting-regulatory-t-cells-in-vivo-a-guide-to-using-anti-cd25-antibodies
CD25+: Role in Immune System Health and Disease
...The expression of CD25 on activated effector T-cells is transient. Once the threat has been neutralized and the immune response subsides, these cells will reduce the amount of CD25 on their surface....
https://biologyinsights.com/cd25-role-in-immune-system-health-and-disease/
Cross talk between human regulatory T cells and antigen-presenting ...
...In this review, we focus on the roles of antigen-presenting cells (APCs) in the generation and function of Tregs in humans. In addition to stimulating the develop-ment of Tregs, APCs activate Tregs and provide signals that induce specialized functional and homing marker expression....
https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.202048746
Autoreactive T cells display altered CD25 expression that changes ...
...As expected, LD-IL-2 increased total Tregs, but autoreactive Tregs required addition of antigen and LD-IL-2 to elicit significant expansion. We found that islet-specific Tregs had lower CD25 expression compared to polyclonal Tregs, but islet-specific Foxp3 ? cells had higher CD25 expression....
https://journals.aai.org/jimmunol/article/198/1_Supplement/127.21/58410/Autoreactive-T-cells-display-altered-CD25
CD4+CD25+regulatory T cells directly act on antigen-presenting cells by ...
...In this study, the authors show that the CD4 + CD25 + regulatory T cells can directly act on APCs (B and dendritic cells [DCs]), and can influence their presentation functions by downregulating costimulatory molecules such as CD80 and CD86....
https://arthritis-research.biomedcentral.com/articles/10.1186/ar-2000-66830
In vitro?expanded human CD4+CD25+ T-regulatory cells can markedly ...
...CD4 + CD25 + T-regulatory (Treg) cells have been shown to critically regulate self- and allograft tolerance in several model systems. Studies of human Treg cells have been restricted by the small number present in peripheral blood and their naturally hypoproliferative state....
https://ashpublications.org/blood/article/104/2/453/18315/In-vitro-expanded-human-CD4-CD25-T-regulatory
The Major Role of T Regulatory Cells in the Efficiency of Vaccination ...
...Vaccination may be combined with anti-CD25 (IL-2R? chain) or anti-programmed cell death protein 1 (PD-1) monoclonal antibodies (mAb) to decrease the Tregs and boost the T/B cell immune response....
https://www.mdpi.com/2076-393X/12/9/992