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Buccolam® Prescribing Guidance
...Unlike unlicensed special products, Buccolam® is available in a single strength only, reducing the risk of confusion and dosing errors. (The National Reporting and Learning System (NRLS) published a signal in February 2012 addressing the risks involved with buccal midazolam preparations)2....
https://www.covwarkformulary.nhs.uk/docs/chapter04/CG037-Buccolam%20Guidance.pdf
Midazolam | Drugs | BNF | NICE
...Initially 2?2.5 mg for 1 dose, to be administered 5?10 minutes before procedure at a rate of approximately 2 mg/minute, dose increased in steps of 1 mg if required, usual total dose is 3.5?5 mg; maximum 7.5 mg per course....
https://bnf.nice.org.uk/drugs/midazolam/
Buccal Midazolam Supporting Guideline v1 - nottsapc.nhs.uk
...For infants aged less than 6 months, treatment should only be in hospital, where monitoring is possible and resuscitation equipment is available. This will be tailored to each patient but in general doses between 0.3-0.5 mg/kg up to a maximum single dose of 10 mg are used in children....
https://www.nottsapc.nhs.uk/media/r04f4pnd/buccal-midazolam-guideline.pdf
BUCCOLAM 2.5mg, 5mg, 7.5mg and 10 mg oromucosal solution
...The doctor will prescribe the appropriate dose of BUCCOLAM the patient needs, generally according to the patient age. The different doses each have a different colour, which is shown on the carton, the tube and the syringe containing the medicine....
https://www.medicines.org.uk/emc/medicine/25527
BUCCOLAM (midazolam) FAQ Patients Bookle
...Your child will need to be prescribed BUCCOLAM® for as long as their healthcare professional feels it is appropriate to provide this medication to stop sudden, prolonged, convulsive, seizures (PACS) they might have....
https://static.neuraxpharm.com/wp-content/uploads/sites/53/2025/12/17113806/nxuk-0125-21-buccolam-faqs-paed-patients-print-final.pdf
BUCCOLAM 2.5mg oromucosal solution - medicines
...Simulated pharmacokinetic parameters for the recommended posology in adults, based on a pharmacokinetic study, suggested that the dose of 10 mg in all adults lead to similar exposure to that of all paediatrics age groups at their corresponding therapeutic doses....
https://www.medicines.org.uk/emc/product/2768/smpc
BUCCOLAM (midazolam) 2.5 mg, 5 mg, 7.5 mg & 10 mg oromucosal solution ...
...use: Midazolam should be avoided in pat ents with a medical history of alcohol or drug ab lam and, subsequently, the effects of midazolam, thus requiring dose adjustments accordingly. Pharmacokinetic interactions with CYP3A4 inhibitors or inducers are more pronounced for oral as compared to oromucosal o...
https://content.neuraxpharm.com/hubfs/UK/Buccolam/PI%20BUC%20NXUK-0125-11%20for%20HubSpot.pdf?hsLang=en
Administering BUCCOLAM® - Buccolam UK
...Parents and carers should only administer a single dose of BUCCOLAM®. Additional doses should not be administered. If seizures re-occur after an initial response, additional doses should not be administered without prior medical advice. The time when BUCCOLAM® was administered must be annotated....
https://buccolam.co.uk/buccolam/administering-buccolam/
Emergency Rescue Medication for Children with Epilepsy
...If child has only been prescribed ONE dose of buccal midazolam for a prolonged seizure and fully recovered, they can have a further dose within the 24 hour period for a SEPARATE seizure event at least 2 hours after the first dose...
https://apps.worcsacute.nhs.uk/KeyDocumentPortal/Home/DownloadFile/1899
PRESCRIBING INFORMATION SHEET - TEWV
...Buccolam® is a licensed preparation of midazolam for buccal (oromucosal) administration. It is licensed for use in children up to 18 years of age, but has also been approved for use in adults in Tees, Esk & Wear Valleys Trust because there isn?t a licensed product available for this age group....
https://www.tewv.nhs.uk/wp-content/uploads/2021/12/Buccolam-carer-information-sheet.pdf
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