Age-Related Considerations in Cardio-Oncology
...Multiple risk factors predispose to anthracycline-induced cardio-toxicity, of which cumulative anthracycline dose is the most critical one....
https://journals.sagepub.com/doi/pdf/10.1177/1074248420968689
Diagnosis, Prevention, Treatment and Surveillance of Anthracycline ...
...Advances in pediatric cancer therapies have dramatically improved the likelihood of survival. As survivors are aging, however, we are now understanding that treatment carries a significant risk of cardiovascular toxicity, which can develop immediately, or even many years after completing therapy....
https://www.mdpi.com/2673-3846/2/1/5
Incidence and risk factors of anthracycline-induced cardiotoxicity in ...
...Population-based data on the incidence of anthracycline-induced cardiotoxicity (AIC) in long-term survivors of childhood cancer is limited. This study?...
https://www.sciencedirect.com/science/article/pii/S2468124522002431
Lifetime Cumulative Dose Documentation - bccancer.bc.ca
...Anthracycline drug manufacturers have suggested maximum lifetime cumulative dose limits beyond which the risk of cardiotoxicity was seen to substantially increase....
https://www.bccancer.bc.ca/pharmacy-site/Documents/Pharmacy%20FAQs/Pharmacy-FAQ-Lifetime-Cumulative-Doses.pdf
Cardiotoxicity in pediatric oncology: a systematic review and meta ...
...Anthracycline-induced cardiotoxicity is a major concern in childhood cancer survivors. Detecting subclinical cardiac dysfunction early is critical, but the accuracy of current diagnostic tools is uncertain. We performed a systematic review and ......
https://www.nature.com/articles/s41390-025-04601-0
Cardioprotective strategies of ACEi/ARBs and beta-blockers against ...
...Background Anthracyclines are routinely used in pediatric oncology but cause dose-dependent cardiotoxicity that compromises long-term survival. Neurohormonal agents such as ACE inhibitors (ACEi), angiotensin receptor blockers (ARBs), and beta ......
https://link.springer.com/article/10.1186/s40959-026-00447-5
Permissive Cardiotoxicity and Determination of Anthracycline Risk With ...
...Anthracyclines are an effective treatment for hematologic malignancies but have significant risk of cardiotoxicity that increases with lifetime dose, ?...
https://www.sciencedirect.com/science/article/pii/S2666084925008095
Pediatric Cardio-Oncology: Screening, Risk Stratification, and ... - MDPI
...Similar to the tertiary prevention of tumors, childhood survivors who took anthracyclines can receive early non-drug treatment under the guidance of physicians, promote cardiorespiratory health, and reduce the cumulative risk of cardiotoxicity....
https://www.mdpi.com/2227-9067/11/7/884
Anthracycline-induced hypertension in pediatric cancer survivors ...
...First of all, the risk of cardiotoxicity is correlated with the total cumulative dose of anthracyclines delivered; greater cumulative doses are linked to higher rates of cardiac events [18]....
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161443/
Exploring Predictive Risk Factors for Myocardial Injury in Children ...
...Anthracycline-induced cardiotoxicity poses a threat to the long-term heart health of childhood cancer survivors; however, early risk assessment remains challenging due to limited predictive tools. While risk prediction models have been developed ......
https://link.springer.com/article/10.1007/s12012-025-10065-9
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